Chesynthesis

The chemical synthesis of L-EGT is very difficult, and several synthesis methods have not achieved the expected yield due to local or complete racemization. The difficulty in synthesis is that it is difficult to prepare the raw material 2-mercaptoimidazole α The acidity of the carbon site makes the reaction prone to racemization. OXIS International was the first company to develop an efficient and commercialized method for synthesizing EGT, and applied for a patent in 1995 by introducing thiol groups into the imidazole ring. However, due to the difficulty in ensuring the safety of chemically synthesized products, the high cost of synthesis and the high selling price of the products, the application of ergot is limited.