The chemical synthesis of L-EGT is very difficult, and several synthesis methods have not achieved the expected yield due to local or complete racemization. The difficulty in synthesis is that it is difficult to prepare the raw material 2-mercaptoimidazole α The acidity of the carbon site makes the
L-ergothioneine (EGT) is a rare natural chiral amino acid strong antioxidant, highly soluble in water, and the only natural 2-thioimidazole amino acid discovered to this day. Due to its unique thione structure and high redox potential, ergot sulfur is less prone to self oxidation under physiological
The biosynthesis of L-ergothione L-EGT was initially isolated from ergot fungi by Tanret et al. in 1909, and it was believed that L-EGT was distributed in conidia rather than sclerotium. Heath and Wildy confirmed that histidine and methionine were precursors of L-EGT synthesis in 1956, 1957 and 1958
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